Endocrine Abstracts

Metformin is considered to be the first choice in the treatment of type 2 diabetes mellitus. Lactic acidosis is a rare life-threatening complication of metformin with approximately 50% overall mortality. Metformin is contraindicated in patients with factors predisposing to lactic acidosis such as impaired renal function (eGFR <30 mL/min). Herein, we present a hemodialysis patient who developed lactic acidosis after inadvertent usage of metformin.Case...

Kidney disease occurs in diabetic patients during disease course in time. Diabetes duration, co-morbid diseases, presence of retinopathy, family history of diabetic nephropathy (DN) predict kidney involvement. Although DN is the initial diagnosis in diabetics with proteinuria, other diseases like primary glomerulonephritis (GN) could be the reason of kidney involvement. DN is increasing in proportion with the increase in diabetes prevalence, and it has been predicted to contin...

Native arteriovenous fistula (AVF) represents the best vascular approach for chronic hemodialysis. It is difficult to create an AVF in diabetic hemodialysis patients due to atherosclerotic changes in the arteries. Although AVF becomes useless after a successful kidney transplant, there is no accepted policy for preserving or ligating AVF. The aim of this study was to compare the fate of AVFs in diabetic and non-diabetic patients after kidney transplantation.<p class="abste...

Background: It is known that obesity-related renal damage,regardless of type 2 diabetes and hypertension, may improve by weight-loss modalities. In this study, we aimed to evaluate the effect of bariatric surgery on glycemic and lipid parameters, anthropometric measurements, renal parameters and urine NGAL (Neutrophil Gelatinase-Associated Lipocalin) levels in obese diabetic or nondiabetic patients who has not respond to medical treatmentMaterials and me...

Weight gain and obesity are frequent problems after kidney transplantation. Potential causes of weight gain are use of immunosuppressive drugs and changes in life style such as dietary intake and insufficient physical activity. This study aimed to evaluate the different general and abdominal obesity criterias and post-transplant weight changes in kidney transplant recipients.Methods: This prospective study included consecutive 112 (62 females, 50 males) ...

Background: Isotretinoin has been used for many years to treat moderate or severe nodulocystic acne, disorders of sebaceous gland and keratinization and in the prevention of skin cancer. Certain types of retinoids may cause abnormalities in serum thyroid function tests by suppressing thyroid stimulating hormone (TSH). However, it is uncertain whether systemic isotretinoin has any effect on thyroid functions.Case: 18 years old woman has admitted to our ho...

Introduction: The most frequently secreted hormone in pituitary adenomas is prolactin, but prolactin and growth hormone co-secretion are also seen at not an uncommon frequency. Co-secretion of growth hormone has also been reported after long-term follow up in the prolactinoma patients which well controlled with cabergoline therapy. In this case report, we aimed to discuss the results of cabergoline therapy in a case of co-secreting GH and prolactine with a normal IGF1 level an...

Case: An 18-years-old female patient suffering from headache, pituitary magnetic resonance imaging (MRI) revealed a lesion compatible with pituitary microadenoma; 8.5×5 mm in size, in the right lateral and extending to the midline of the pituitary gland. Cabergoline treatment was initiated in the external center with a prolactin level of 77 ng/ml and no other pituitary hormone abnormality. Unplanned pregnancy occurred in the patient who continued this treatment for about ...

Background: After the diagnosis of corticotropin (ACTH) dependent Cushing’s syndrome established, its cause must be determined. Cushing’s disease (CD) is caused by corticotropin (ACTH) secreting adenomas and it accounts for roughly 75-80% of all endogenous Cushing’s syndrome. These adenomas are almost always benign. Renal cell carcinoma (RCC) is the most seen kidney cancer. In this case report, a presentation of a patient who was diagnosed with concurrent CD and...

Background: Acromegaly is a rare endocrine disorder characterized by sustained hypersecretion of growth hormone (GH) with concomitant elevation of insulin-like growth factor I (IGF-I) associated with acral enlargement, sleep apnea, cardiovascular and metabolic disorders. Its annual incidence is approximately six per million people. The most common cause of acromegaly is a somatotroph (growth hormone-secreting) adenoma of the anterior pituitary.Methods: A...